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Clinical Trials by Specialty

ADULT TYPE 2 DIABETES

IOQC: Two Approaches to Escalate Lispro Therapy in Patients with Type 2 Diabetes Mellitus Not Achieving Adequate Glycemic Control on Basal Insulin Therapy and Oral Agents Alone. For more information contact Michelle at 309-683-5356.

EPILEPSY

Lundbeck: A prospective, open-label study of the structure and function of the retina in adult patients with refractory complex partial seizures treated with vigabatrin (Sabril®). For more information contact Mary 309-624-8401.

SP902: A historical-controlled, multicenter, double-blind, randomized trial to assess the efficacy and safety of conversion to Lacosamide 400mg/day Monotherapy in subjects with partial-onset seizures. For more information contact Mary 309-624-8401.

P904: A multicenter, open-label extension trial to assess the long-term use of Lacosamide Monotherapy and adjunctive therapy in subjects with partial-onset seizures. Subjects must have completed the SP902 study. For more information contact Mary 309-624-8401.

UCB 1358: A randomized, double-blind, placebo-controlled, multicenter, parallel-group study to evaluate the efficacy and safety of brivaracetam in subjects with partial onset seizures. Fore more information contact Mary 309-624-8401.

UCB 1379: An open-label, multicenter, follow-up study to evaluate the long-term safety and efficacy of brivaracetam used as adjunctive treatment in subjects with partial onset seizures. Subjects must have completed the 1358 study. For more information contact Mary 309-624-8401.

V-Compas: A post-market, long term, prospective, observational, multi-site outcome study to follow the clinical course and seizure reduction of patients with refractory seizures who are being treated with adjunctive VNS (vagus nerve stimulation) therapy. For more information, contact Sarah at 309 655-7837.

GASTROPARESIS

Enterra: Humanitarian use of the Enterra Therapy Gastric Stimulation System, indicated for the treatment of patients with long term, uncontrolled nausea and vomiting related to gastroparesis. HDE #990014. For more information contact Kim at 309-655-4229.

HEART FAILURE

ATMOSPHERE: A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of both aliskiren monotherapy and aliskiren/enalapril combination therapy compared to enalapril monotherapy, on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV). For more information contact Michelle at 309-683-5356.

TOPCAT: A study to determine if the drug spironolactone, in addition to standard therapies, can reduce cardiovascular events and hospitalizations in patients with congestive heart failure. For more information contact Marsha at 309-691-4410.

Idiopathic Intracranial Hypertension

Nordic: A Multicenter, Double-blind, Randomized, Placebo-controlled Study of Weight-Reduction and/or Low-Sodium Diet plus Acetazolamide vs Diet plus Placebo in Subjects with Idiopathic Intracranial Hypertension with Mild Visual Loss. For more information contact Mary 309-624-8401.

MULTIPLE SCLEROSIS

ASCEND: A study to evaluate the efficacy of Tysabri in reducing disability progression in patients with Secondary Progressive Multiple Sclerosis (SPMS). For more information contact Kim C. at 309-655-4727.

Stratify 2: Study to check presence of JCV antibody in patients with Relapsing Multiple Sclerosis receiving or considering treatment with Tysabri. For more information contact Kim C. at 309-655-4727.

NEUROSURGERY

A prospective study of the relationship of neuropsychological and motor performance parameters with magnetic resonance imaging in athletes with mild traumatic brain injury. For more information contact Sarah at 309-655-7837.

Exogen: A Prospective, Multi-center, Double-blind, Randomized, Placebo Controlled Pivotal Study of Ultrasound Therapy as Adjunctive Therapy for Increasing Posterolateral Fusion Success Following Single Level Posterior Instrumented Lumbar Surgery (All enrolled patients will have undergone single level lumbar fusion). For more information contact Sarah at 309-655-7837.

HSRT: A Pilot Study Examining the Role of Pre-Operative Hypofractionated Stereotactic Radiation Therapy followed by Surgery in the Treatment of Cerebral Metastatic Disease. For more information, contact Sarah 309 655-7837.

Licox: A Pilot Study Examining the Role of Brain Tissue Oxygen Monitoring in the Detection of Cerebral Vasospasm Secondary to High Grade Aneurysmal Subarachnoid Hemorrhage. Inpatient study. For more information, contact Sarah at 309 655-7837.

Use of Neuroimaging to Study the Pain Network in Patients of Trigeminal Neuralgia. For more information, contact Sarah at 309 655-7837.

PEDIATRICS

Characterization of Plasma Factor XIII Antigen and Activity in Very Low Birth Weight Premature Neonates: Correlation with the Incidence and Outcome of Intra-ventricular Hemorrhage: A study to measure cord blood antigen concentration and activity of Factor XIII in premature neonates to identify a correlation between low Factor XIII activity and the incidence of intraventricular hemorrhage (IVH). For more information contact Tammy at 309-624-9448

Eltrombopag PETIT: Eltrombopag in PEdiatric patients with Thrombocytopenia from ITP: A study to investigate the efficacy, safety, tolerability and pharmacokinetics of eltrombopag, a thrombopoietin receptor agonist, in previously treated pediatric patients with chronic idiopathic thrombocytopenic purpura (ITP). For more information contact Tammy at 309-624-9448

MPEX: A phase 3, open label, randomized trial to evaluate the safety and efficacy of MP-376 inhalation solution (aeroquin) versus tobramycin inhalation solution in stable cystic fibrosis patients MPEX 209. For more information contact Tammy at 309-624-9448

PULMONARY/CRITICAL CARE

Altor Bioscience: Sepsis with Acute Lung Injury/Acute Respiratory Distress Syndrome Title: Efficacy and Safety Evaluation of ALT-836 in Patients with Sepsis and Acute Lung Injury/Acute Respiratory Distress Syndrome. For more information contact Kimberly or Ashley at 309-672-5682.

Furiex Pharmaceuticals: Community Acquired Pneumonia with PORT score of II or Greater Title: A Randomized, Controlled, Double-Blind, Multicenter, Phase 2 Study of the Safety/Tolerability and Efficacy of JNJ-32729463 Compared With Moxifloxacin for the Treatment of Subjects Requiring Hospitalization for Community-Acquired Bacterial Pneumonia (CABP) With a PORT Score of II or Greater. For more information contact Kimberly or Ashley 309-672-5682.

GSK NAI114373: Influenza or Influenza-Like-Illness Title: A Phase III international, randomized, double-blind, double-dummy study to evaluate the efficacy and safety of 300 mg or 600 mg of intravenous zanamivir twice daily compared to 75 mg of oral oseltamivir twice daily in the treatment of hospitalized adults and adolescents with influenza. For more information contact Kimberly or Ashley 309-672-5682.

STROKE

Iris: A study to test the effectiveness of a new treatment (pioglitazone) for preventing future strokes and heart attacks among persons with a recent stroke or TIA. For more information contact Judi at 309-624-3240.

Respect PFO: A study for patients with Stroke and Patent Foramen Ovale (PFO), comparing an investigational PFO occluder device, to current standard of care treatment in preventing another stroke. For more information contact Judi at 309-624-3240.

MISC

CHOICE: This is a registry to collect information and evaluate outcomes of patients who undergo stenting of a blocked carotid artery because they are high risk for the standard of care, which is carotid endarterectomy surgery. For more information contact Marsha at 309-691-4410.

For information regarding other clinical trials in the area please visit the following links.

Peoria Radiology Research and Education Foundation
Central Illinois Radiology Associates
http://peoria.medicine.uic.edu/departments___programs/radiology/research/

Illinois Cancer Care
http://www.illinoiscancercare.com/index.cfm?pageID=6

Illinois Lung Institute
Peoria Pulmonary Associates, Ltd.
http://www.illung.com/

OSF Medical Group-Clinical Research Center
http://www.osfmedicalgroup.org/peoria/clinical-studies.html

Saint Jude-Midwest Affiliate
http://www.stjuderesearch.org/

Children's Hospital of Illinois
http://www.childrenshospitalofil.org/

University of Illinois College of Medicine at Peoria
http://peoria.medicine.uic.edu/research